During her time at the Science History Institute, Simone investigated chemicals as key actors in the story of the global waste economy. Chemicals, she argues, provide the basis of our comfortable modern way of life. They let themselves be molded and formed into myriad compounds making up industrial and commercial products ranging from plastics to pesticides and pharmaceuticals. At the same time, they also have the ability to permeate into our bodies and other biological organisms and do great harm to our health and environment. After the environmental turn in the 1970s, chemicals’ effects turned out to be particularly gruesome when environmental and consumer laws deemed them unfit for consumption in one country while economic logic still allowed their commodification for other markets. Almost routinely, chemicals traveled with hazardous-waste barges, as outlawed pharmaceutical and agricultural products or children’s toys from industrial places in the global North to less-developed places in the global South. There, their effects on human health and the environment manifested the inequality of a life’s worth alongside the North’s ecological debt toward the South. By focusing her research on the role of chemicals within the global waste economy, Simone worked to shed new light on the political and economic processes so far exhibited in global waste studies while also contributing to a material history of environmental history writing.